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KMID : 0376219840210010201
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Chonnam Medical Journal
1984 Volume.21 No. 1 p.201 ~ p.206
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Effect of Rodenticide Vacor Poisoning on Insulin Binding to Adipocytes and Erythrocytes of Rats
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李民化/Lee, Min-wha
李泰熙/梁誠烈/朴昞柱/Lee, Taie-hee/Yang, Sung-yeul/Park, Byung-ju
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Abstract
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Vacor, when administered orally at a small dose (5mg/kg body weight) to rats, caused a glucose intolerance without apparent fasting hyperglycemia. At the same time, Vacor caused a reduction of insulin binding to epididymal adipocytes of rats. Scatchard analysis revealed that the reduction of adipocyte insulin binding in Vacor-poisoned rats is mainly accounted for by a decrease in the insulin receptor concentrations. The erythrocyte insulin binding, however, was not affected by Vacor-poisoning.
These results suggest that Vacor-induced decrease in the insulin receptor concentrations of peripheral tissues such as adipocytes causes a reduced tissue response to insulin and eventually leads to glucose intolerance in Vacor-poisoned rats.
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